From Stanford Medicine. I go for as much coffee as I can get, 8-12 cups a day. How long before your doctor has a coffee protocol?
Drink for your heart: Caffeine may counter age-related inflammation, cardiovascular disease
There’s a clear connection between chronological age, chronic inflammation, cardiovascular disease and… coffee consumption.
More than 90 percent of all noncommunicable diseases of aging are
associated with chronic inflammation. And more than 1,000 papers have
provided evidence that chronic inflammation contributes to many cancers, Alzheimer’s disease and other dementias, cardiovascular disease, osteoarthritis and even depression.
It’s also well known — well, at least among the scientists who study this kind of thing — that caffeine intake is associated with longevity. Now, Stanford immunologists David Furman, PhD, and Mark Davis, PhD, and their colleagues have revealed a likely reason why this may be so.
In a study published in Nature Medicine, the researchers conducted
extensive analyses of blood samples, survey data and medical and family
histories obtained from more than 100 human participants in a multiyear
study. Their search revealed a fundamental inflammatory mechanism
associated with human aging and the chronic diseases that come with it.
In short, this mechanism becomes increasingly likely to kick into high
gear as the number of candles on our birthday cake marches relentlessly
toward infinity.
The study implicates this same inflammatory process as a driver of
cardiovascular disease and increased rates of mortality overall.
Metabolites, or breakdown products, of nucleic acids — the molecules
that serve as building blocks for our genes — circulating in the blood
can trigger this inflammatory process big-time, the study found.
Injecting these substances into mice produced massive systemic
inflammation, sent their blood pressure soaring and wreaked havoc with
their kidneys, among other nasty consequences.
Intriguingly, caffeine and its own metabolites — whose molecular
structure, intriguingly, bears a strong family resemblance to the
nucleic-acid metabolites — blocked the abysmal action of the latter,
possibly explaining why coffee drinkers tend to live longer than
abstainers.
Now, the good news: Not all older people, as the study showed, are
cursed with the age-related inflammatory hyperdrive discovered by the
investigators. And when Furman, Davis et al. looked at the
extremes — older people with low levels of this type of inflammation
were only one-eighth as likely as the high-level older people to have
high blood pressure. They were also eight times as likely to report
having at least one close blood relative who had lived to the age of 90
or older. And of the people in the study who were 85 or more years old
in 2008, when the long-term longitudinal study began, those with low
levels of the identified type of systemic inflammation were
substantially more likely to still be alive in 2016, eight years later.
And sure enough: The study participants with the lowest activation
levels of the nasty inflammatory mechanism were the ones who, according
to extensive questionnaires, reported the highest caffeine intake.
If that doesn’t enable your coffee addiction, nothing will. Oh, and
by the way, black tea and dark chocolate contain compounds similar to
caffeine.
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